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The Coronin Family of Proteins (Hardcover, 2009 ed.)
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The Coronin Family of Proteins (Hardcover, 2009 ed.)
Series: Subcellular Biochemistry, 48
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The Coronin Family of Proteins Christoph S. Clemen, * Vasily
Rybakin and Ludwig Eichinger he coronins, first described in
Dictyostelium discoideum in 1991, have meanwhile been detected in
all eukaryotes except plants. They belong to the superfamily of
WD40-repeat Tproteins and represent a large family of proteins,
which are often involved in cytoskeletal functions. Phylogenetic
studies clearly distinguish 12 subfamilies of which six exclusively
occur in vertebrates. In the present book we have made a sincere
attempt to provide a comprehensive overview on all aspects of
coronin proteins including history, structure, subcellular
localization and function in different organisms. In addition, we
also included a general overview on the WD40 family of proteins and
the structurally related Kelch family. The book should be of
interest for scientists outside the field, but is more importantly
intended as a fast and competent guide for newcomers as well as
doctoral and postdoctoral scientists to coronin research in all its
facets. The book is divided into four major sections. It provides
in the first part an introduction into two superfamilies of
proteins with p-propellers, the WD40- and the Kelch-family. Lynn
Cooley and Andrew M. Hudson provide evidence that the WD40- and
Kelch-repeat families most likely did Figure 1. Condensed
phylogenetic tree of the coronin protein family. The tree
constitutes the basis of a new nomenclature and shows the
evolutionary relationship of the twelve coronin subfamilies
{CRN1-CRN12). See also chapter 11-2 by Reginald O. Morgan and M.
Pilar Fernandez
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