Staphylococcus epidermidis often colonizes the skin and mucous
membranes of the human body, as part of its normal microflora.
However, when a rupture of the cutaneous surface occurs,
staphylococci can enter the host and become pathogenic. Therefore,
S. epidermidis has emerged in recent years as a major nosocomial
pathogen associated with infections of implanted medical devices.
Staphylococci adhere to such devices and have the ability to
develop biofilms, which constitutes an important virulence factor
and the most relevant pathogenic mechanism of staphylococcal
infection. The work presented in this book aimed at evaluating the
adhesion and biofilm formation capabilities of S. epidermidis
clinical strains to biomaterials. This book, hence, covers
important topics such as: the surface properties that affect
initial bacterial adhesion as well as of ways to prevent it; the
properties of mature biofilms and the phenotypic differences
between sessile and planktonic cells; the assessment of cell wall
and extracellular matrix proteins profiles to evaluate their
importance on the process of biofilm formation, among others.
General
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