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Books > Medicine > Nursing & ancillary services > Biomedical engineering
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Tracer Kinetics in Biomedical Research - From Data to Model (Paperback, Softcover reprint of the original 1st ed. 2002)
Loot Price: R6,367
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Tracer Kinetics in Biomedical Research - From Data to Model (Paperback, Softcover reprint of the original 1st ed. 2002)
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The use of mathematical modeling techniques in biomedical research
is playing an increasingly important role in the understanding of
the pathophysiology of disease processes. This includes not only
understanding mechanisms of physiological processes, but also
diagnosis and treatment. In addition, its introduction in the study
of genomics and proteomics is key in understanding the functional
characteristics of gene expression and protein assembly and
secretion. Finally, with the increasing complexity and associated
cost of drug development, modeling techniques are being used to
streamline the process. This book is designed to give the reader
the mathematical and statistical information necessary to design
tracer kinetic studies, to use noncompartmental methodologies
and/or to develop multicompartmental models to interpret the data.
The book starts with a review of fundamentals of radioactive and
stable isotope tracer kinetics and then proceeds with a description
of the noncompartmental and multicompartmental modeling
methodologies to study systems in the steady state.The focus is on
understanding the basic assumptions inherent in the methodologies
and the underlying mathematics and statistics, on discussing how to
assess how 'good' a model is and on giving some hints on how better
to design kinetic studies, in order to increase the probability of
a successful study and to ensure the maximal information content in
the experimental data to be extracted. The book has an extensive
section on parameter estimation, i.e., fitting models to data,
first in general terms and then specifically related to
noncompartmental and compartmental models. This is written from a
basic point of view, and is intended to remove the mystery from the
'black box' of computer optimization software. Finally, a special
application often found in tracer kinetic analysis,
precursor-product relationships, is discussed. Throughout the book,
the goal is to provide even the novice with sufficient background
so that he/she can feel comfortable. A number of case studies,
based upon real experimental data, are carried through the text.
Other examples illustrate specific points. All data examples are
provided on a floppy disk.
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