Neovascularization isanormalphaseoftissue repair mechanlsm. In
theeye, however, sproutingofnewvessels
withinavasculartissuesandtheirgreatertendencytobleed
havedetrimentaleffectsonvision. Diabeticretinopathy, corneal
neovascularization, age-related macular degeneration, retinal
veinocclusion, andretinopathy of prematurity are major causes of
blindness. In all, uncontrolled
proliferationofnewvesselsistheunderlying
pathologicalcauseleadingtotheinexorablelossofvision. Development of
lasertechnologiesandtheir wide use in ophthalmology have
broughtsomehopeforthetreqtment of these diseases. However,
itbecameevident that direct
closureofthenewvesselsand/orablationoflargepartsof
thetissuearenotidealsolutionstotheproblem. Recent advances in
molecular biology and genetic engineering have fosteredbasic
knowledge regarding the growth factors and intercellular messengers
and their association with theproliferationofnew blood vessels.
These latter findings sparked a renewed interest in Michaelson's
"X-factor" ofocular neovascularization and opened avenues for
possible innovative therapeutic approaches. Therefore, the
suggestion to organize an international gathering of clinicians and
scientists interested in problems of ocular circulation and
neovascularization was received with great enthusiasm. Unanimously,
it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson,
theinnovativescientist, the greatclinician,
theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The
meeting was highlighted by the outstanding atmosphere of
friendshipandscientif.ic exchanges. This book mirrors the
information delivered and includes a
selectionofpapersfromthescientificprogram.
Theorganizationofthismeetingandthepublicationof
thebookwouldnothavebeenpossiblewithouttheharmonious
teameffortsmadebytheInternational, ScientificandLocal Committees. I
am thankful tothe chairpersons of the varioussessionsfortheirtime,
keeninterestandendeavor for the realizationofahighscientific level.
I also deeplyacknowledgethehelpand&upportofArnallPatz, Bob
Murphy, BertGlaser, RobertFrank, LarryHjelmeland, Gordon
Klintworth, Neville Welsh, Charles Riva, Alec Garner,
DesmondArcher, EphraimFriedman, MyronYanoff, MosheLahav, Willem
Manschot, Hans-WaltherLarsenand Masanobu Uyama. The powerful
stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas,
GiselleSoubrane, MosheIvry, YuvalYassur and Sue and Peter
Ballenwasmost instrumental in the realizationofthese"dreams."
Asalways, Iwasfortunate
tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen,
Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra.
Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave
been possible without theincalculablehelp and indefatigable typing
and councilofJudithFisher, whoseconded me in
selectingthepapersandeditingthebook."
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