The development of liposomes as a drug delivery system has
fluctuated since its introduction in the late 1960's by A.D.
Bangham. While academic research of liposomes as a model membrane
system has always flourished, as the exponential growth of papers
can testify, the application of these findings to medically useful
products has gone through several crises. Following the original
optimism in the 70's and early 80's, a period of severe skepticism
ensued at the end of the 80's and beginning of the 90's,
culminating in a moderate but real optimism in the mid 90's, as a
result of a successful launch of the first products in the US and
Europe.
In this collection of papers, the editors have gathered the most
promising ideas, approaches, applications and commercial
developments, thereby presenting an up-to-date compilation of the
present status of the field. This includes such broad areas as
anti-cancer chemotherapy immune stimulation and infectious
diseases. Currently, the major areas of progress are in delivery of
anti-fungal agents by conventional liposomes or lipid-based
carriers and systemic anticancer therapy using long-circulating
liposomes. The future applications as characterized by the
direction of present day research is in specific targeting and
delivery of informational molecules such as DNA plasmids (genes),
antisense oligonucleotides or ribozymes. Other future developments
may be in topical delivery, vaccination and in diagnostics.
Features of this book:
Contributions from almost all the leading labs in the field
Up-to-date, critical reviews bridged by editors'
introductions
Organized into a logical framework."
General
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