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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Actions of Progesterone on the Brain (Paperback, Softcover reprint of the original 1st ed. 1985)
Loot Price: R2,778
Discovery Miles 27 780
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Actions of Progesterone on the Brain (Paperback, Softcover reprint of the original 1st ed. 1985)
Series: Current Topics in Neuroendocrinology, 5
Expected to ship within 10 - 15 working days
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Total price: R2,798
Discovery Miles: 27 980
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It is well established that progesterone plays a role in the brain
and hypophysis as a facilitator and inhibitor of sexual behavior
and gonadotropin release in the female rat (Everett 1961; Caligaris
et al. 1971; Brown-Grant and Naftolin 1972; Dorner 1972; Meyerson
1972; Barraclough 1973; Goldman and Zarrow 1973; Mann and
Barraclough 1973; Freeman et al. 1976; Feder and Marrone 1977;
Goodman 1978; Attardi 1981), guinea pig (Morin and Feder 1974), and
primates (Odell and Swerdloff 1968; Spies and Niswender 1972;
Yamaji et al. 1972; Karsch et al. 1973; Dierschke et al. 1973;
Knobi11974; Clifton et al. 1975). In an attempt to learn whether a
specific progesterone uptake mechanism exists in the brain and the
hypophysis, the distribution and retention pattern of radioactivity
after in vivo injection of labeled progesterone was studied. Early
work of Kato (1963) did not show a selective uptake of
radioactivity in the hypo- thalamus of immature and estrogen-primed
immature rats after injection oflow- specific-activity
[14C]progesterone, but some tendency of the reticular formation to
take up radiation was observed. Laumas and Farooq (1966) reported
that after intravenous administration of labeled progesterone to
ovariectomized estrogen- treated rats, radioactivity in the brain
and pituitary appeared to show a very slight, insignificant
increase 1-2 min after injection, but the uptake pattern was not
definite, as had been seen with estradiol. Seiki et al.
General
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