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Mammalian Amino Acid Transport - Mechanism and Control (Hardcover, 1992 ed.)
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Mammalian Amino Acid Transport - Mechanism and Control (Hardcover, 1992 ed.)
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Amino acid transport is a part of each of two larger subjects,
amino acid metabolism and the biomembrane transport of various .
small molecules and ions. Nevertheless in this volume we treat
amino acid transport as more than a fragment of either of these two
larger subjects. A more comprehensive approach is justified when we
remember two historic and ongoing aspects of the title subject.
First, amino acid transport had its beginning and acquired a
distinct momentum (even if somewhat interrupted from 1913 until
about 1945) as amino acid metabolism with the central and pioneer
work of Van Slyke and Meyer in 1913. The reviews in this volume
will show that it steadily becomes a larger aspect of amino acid
metabolism, broadly perceived. These chapters will show for how
many organelles, cells, tissues, organs and organ systems, the
transmembrane compartmentations and flows of amino acids play very
large parts in their fundamental biological relations. The authors
here are tending collectively to evaluate an understanding of amino
acid flows across biomernbranes, and the regulation of these flows,
as necessary to an ultimate understanding of the full range of
development and metabolism. Such an understanding goes far beyond
the purely substrate-destabilizing contributions by enzymes, which
have often been arbitrarily limited to that conceptual entity, "the
cell," and which for so long a splendid time had most of
biochemical research attention.
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