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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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Inflammation and the Microcirculation (Paperback)
Loot Price: R1,166
Discovery Miles 11 660
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Inflammation and the Microcirculation (Paperback)
Series: Colloquium Series on Integrated Systems Physiology
Expected to ship within 10 - 15 working days
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Total price: R1,186
Discovery Miles: 11 860
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The microcirculation is highly responsive to, and a vital
participant in, the inflammatory response. All segments of the
microvasculature (arterioles, capillaries, and venules) exhibit
characteristic phenotypic changes during inflammation that appear
to be directed toward enhancing the delivery of inflammatory cells
to the injured/infected tissue, isolating the region from healthy
tissue and the systemic circulation, and setting the stage for
tissue repair and regeneration. The best characterized responses of
the microcirculation to inflammation include impaired vasomotor
function, reduced capillary perfusion, adhesion of leukocytes and
platelets, activation of the coagulation cascade, and enhanced
thrombosis, increased vascular permeability, and an increase in the
rate of proliferation of blood and lymphatic vessels. A variety of
cells that normally circulate in blood (leukocytes, platelets) or
reside within the vessel wall (endothelial cells, pericytes) or in
the perivascular space (mast cells, macrophages) are activated in
response to inflammation. The activation products and chemical
mediators released from these cells act through different
well-characterized signaling pathways to induce the phenotypic
changes in microvessel function that accompany inflammation. Drugs
that target a specific microvascular response to inflammation, such
as leukocyte-endothelial cell adhesion or angiogenesis, have shown
promise in both the preclinical and clinical studies of
inflammatory disease. Future research efforts in this area will
likely identify new avenues for therapeutic intervention in
inflammation.
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