The genus Borrelia, in the spirochete phylum, is not closely
related to any other bacteria and has a highly unusual genome
composed of a linear chromosome and multiple circular and linear
plasmids that appear to be in a constant state of rearrangement,
recombination, and deletion. The determination of the genome
sequence of Borrelia strains has facilitated tremendous advances in
understanding this genus at the molecular and cellular level, as
well as the pathogenesis of Lyme disease and relapsing fever. In
recent years, there has been an explosion of new insights into the
molecular biology, genetics, physiology, and ecology of Borrelia
and its tick/vertebrate life cycle. This research is of particular
importance as the incidence of Lyme borreliosis continues to
increase. Written by renowned scientists who have made seminal
contributions to the field, this book is a comprehensive guide to
the pathogenic Borrelia, providing researchers, advanced students,
clinicians, and other professionals with an encyclopedic overview
of the molecular biology of this important genus and the
pathogenesis of diseases. Leading authorities have made
contributions on topics such as Borrelia genomics, DNA replication,
gene regulation, transcriptomics, proteomics, metabolism and
physiology, cellular structure, motility and chemotaxis, genetic
manipulation, evolutionary genetics, ecology, tick interactions,
Lyme disease and relapsing fever pathogenesis, animal models, host
response, detection, and vaccines. The volume is essential for
anyone involved in Borrelia research and is strongly recommended
for microbiologists, immunologists, and physicians involved in
spirochete research, Lyme borreliosis, or relapsing fever. The book
is a recommended reference volume for all microbiology libraries.
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