The field of pediatric oncology encompasses four groups of
malignancies - acute leukemias, brain tumors, lymphomas and solid
tumors. 1'he history, diagnosis and management of children with
acute leukemias and lymphomas has been thoroughly examined in
several excellent textbooks of pediatric hematology and oncology.
Bl"ain tumors have historically been managed by neurosurgeons and
radiation therapists. 1'he role of the pediatric oncologist in the
management of these patients is evolving. This book was written to
provide a thorough historical evaluation of the most frequent solid
tumors of children. A detailed examination of the natural history
of these tumors is essential to the design and evaluation of
therapeutic trials. The highly lethal nature of many of these
tumors, the occurrence of some of them at several different primary
sites and the rarity of these tumors have made systematic study of
them difficult. Conclusions regarding the efficacy of a particular
modification of the therapeutic strategy can be strongly influenced
by the assumed natural history of the tumor. I have tried to
develop as accurateJy as the literature would allow a picture of
the natural history of the common malignant solid tumors, knowing
that the image would be imperfect. I adopted a convention which was
employed in all graphs constructeil from case reports summarized
from the literature.
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