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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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DNA Repair Protocols - Eukaryotic Systems (Paperback, 1999 ed.)
Loot Price: R4,328
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DNA Repair Protocols - Eukaryotic Systems (Paperback, 1999 ed.)
Series: Methods in Molecular Biology, 113
Expected to ship within 10 - 15 working days
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The field of eukaryotic DNA repair is enjoying a period of
remarkable growth and discovery, fueled by technological advances
in molecular biol- ogy, protein biochemistry, and genetics. Notahle
achievements include the molecular cloning of multiple genes
associated with classical human repair disorders, such as xeroderma
pigmentosum, Cockayne syndrome, and ataxia telangiectasia;
elucidation of the core reaction of nucleotide excision repair
(NER); the discovery that certain NER proteins participate not only
in repair, but also in transcription; recognition of the crucial
role played by mismatch repair processes in maintenance of genome
stability and avoidance of cancer; the findings that the tumor
suppressor protein p53 is mutated in many types of cancer, and has
a key role in directing potentially malignant, genotoxin-dam- aged
cells towards an apoptotic fate; and the discovery and elaboration
of DNA darnage (and replication) checkpoints, which placed repair
phenomenol- ogy firmly within a cell-cycle context. Of course, much
remains to be learned about DNA repair. Tothat end, DNA Repair
Protocols: Eukaryotic Systems is about the tools and techniques
that have helped propel the DNA repair field into the mainstream of
biological research. DNA Repair Protoco/s: Eukaryotic Systems
provides detailed, step-by- step instructions for studying manifold
aspects of the eukaryotic response to genomic injury. The majority
of chapters describe methods for analyzing DNA repair processes in
mammalian cells. However, many ofthose techniques can be applied
with only minor modification to other systems, and vice versa.
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