IGFs:Local Repair and Survival Factors Throughout Life Span (Hardcover, 2010 ed.)

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Research and Perspectives in Endocrine Interactions
Release date:	December 2009
First published:	2010
Editors:	David Clemmons • Iain C.A.F. Robinson
Dimensions:	235 x 155 x 15mm (L x W x T)
Format:	Hardcover
Pages:	157
Edition:	2010 ed.
ISBN-13:	978-3-642-04301-7
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Medicine > Clinical & internal medicine > Endocrinology > General Promotions
LSN:	3-642-04301-1
Barcode:	9783642043017

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!