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Antimicrobial Drugs - Chronicle of a twentieth century medical triumph (Hardcover)
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Antimicrobial Drugs - Chronicle of a twentieth century medical triumph (Hardcover)
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Between 1935 and 1944 the field of microbiology, and by implication
medicine as a whole, underwent dramatic advancement. The discovery
of the extraordinary antibacterial properties of sulphonamides,
penicillin, and streptomycin triggered a frantic hunt for more
antimicrobial drugs that was to yield an abundant harvest in a very
short space of time. By the early 1960s more than 50 antibacterial
agents were available to the prescribing physician and, largely by
a process of chemical modification of existing compounds, that
number has more than tripled today. We have become so used to the
ready availability of these relatively safe and highly effective
'miracle drugs' that it is now hard to grasp how they transformed
the treatment of infection.
This book documents the progress made from the first tentative
search for an elusive 'chemotherapy' of infection in the early days
of the twentieth century, to the development of effective antiviral
agents for the management of HIV as the millennium drew to a close.
It also offers a celebration of the individuals and groups that
made this miracle happen, as well as examining the inexorable rise
of the global pharmaceutical industry, and, most intriguingly, the
essential input of luck.
Infection still maintains a high profile in both medicine and the
media, with the current threats of 'superbugs' such as MRSA
acquired in hospital, and a potential resistance to antibiotics.
This book tracks the history of antimicrobial drugs, a remarkable
medical triumph that has provided doctors with an amazing armoury
of safe and effective drugs that ensure that reversion to the
helpless state of the fight against infection witnessed in the
early 1900s isextremely unlikely. This timely compendium
acknowledges the agents that have surely led to the relief of more
human and animal suffering than any other class of drugs in the
history of medical endeavour.
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