Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Immunosuppression and Human Malignancy (Hardcover, 1989 ed.)
Loot Price: R3,238
Discovery Miles 32 380
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Immunosuppression and Human Malignancy (Hardcover, 1989 ed.)
Series: Contemporary Immunology
Expected to ship within 12 - 17 working days
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The immune system can deal effectively with the majority of viruses
and bacteria, less effectively with parasites, and very poorly with
cancer. Why is this so? Why are McFarlane Burnet's and Lewis
Thomas' predictions that the immune system is in volved in ridding
the body of cancer cells, encapsulated in the catchy phrase
"immunologic surveillance," so difficult to experi mentally
establish? Cancer differs from infectious agents in being derived
from the host. Hence, it has been postulated that cancer cells lack
anti gens that the immune system can recognize. They are not "im
munogenic. " However, this argument is seriously weakened by the
existence of numerous human autoimmune diseases, in which the
immune system effectively recognizes and attacks a va riety of self
tissues. Thus, the potential clearly exists for recogni tion of the
surfaces of tumor cells. Professor Naor and his colleagues have
written a book that explores another possible reason: cancer cells
are recognized by the immune system-but is it possible that the
consequence of recognition is inhibition of the immune system-by
suppressor T cells or macrophages? The evolution of the malignant
state may only occur in individuals who develop this suppression.
This book reviews the evidence that suppressor cells, poorly
characterized and difficult to study, may be of fundamental im
portance in cancer. In fact, our incapacity to understand the na
ture of suppressor cells and their mode of action is one of the ma
jor problems in immunology research today."
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