Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Rna Viruses: Host Gene Responses To Infections (Hardcover)
Loot Price: R7,037
Discovery Miles 70 370
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Rna Viruses: Host Gene Responses To Infections (Hardcover)
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Total price: R7,057
Discovery Miles: 70 570
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This is the first comprehensive book on human/animal gene responses
to RNA viral infections, including prevalent, emerging and
re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus,
influenza virus and many others. Human gene responses are reviewed
by leading virologists worldwide in the following aspects: (i) the
altered gene expression profiles at the transcriptional and
translational levels detected with cutting-edge technologies such
as cDNA microarray and proteomics; (ii) host innate and adapted
immune responses to viral replication in target organs; (iii)
virus-activated signal transduction pathways in cell survival,
apoptosis and autophagosomal pathways; and (iv) the small
interfering RNA/microRNA-mediated gene silencing pathway, a
recently characterized new host defense mechanism against viral
infection. Organized into 27 highly accessible and well-illustrated
chapters, this volume explores state-of-the-art knowledge of the
molecular mechanisms of RNA virus infection and host virus
interactions. This comprehensive compilation of the altered gene
expression profiles and signal transduction pathways in host cells
in response to the majority of human/animal RNA viruses opens new
directions for basic and clinical research on viral pathogenesis,
and also provides valuable biomarkers for researchers to select
gene targets in the development of diagnostic tests and antiviral
therapeutics for a number of infectious diseases.
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