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Hepatobiliary Transport in Health and Disease (Hardcover)
Loot Price: R5,813
Discovery Miles 58 130
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Hepatobiliary Transport in Health and Disease (Hardcover)
Expected to ship within 12 - 17 working days
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One major function of the liver is the uptake of endo- and
xenobiotics from the bloodstream and their excretion into bile. The
transport systems involved in hepatobiliary transport have been
recently cloned and characterized at the molecular level and it is
becoming clear that mutations and polymorphisms of individual
transporter molecules underlie a variety of liver diseases.
Furthermore, new research has shown that bile acids, whose function
in digestion is long known, also behave as signal molecules in a
variety of organs, including the intestinal and biliary epithelia,
sinusoidal endothelial and immune cells. This book provides indepth
surveys on the structure and function of transport molecules
involved in hepatobiliary transport, on the role of different bile
acids receptors in various organs and their function in health and
disease, the mechanisms of bile salt-induced apoptosis and
hepatocyte protection, and the role of transporter mutations as
causes and modifiers of liver diseases. The book will be of
interest not only for biochemists, structural chemists and
biologists, but also for clinicians.
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