Systems Pharmacology and Pharmacodynamics (Paperback, Softcover reprint of the original 1st ed. 2016)

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	AAPS Advances in the Pharmaceutical Sciences Series, 23
Release date:	July 2018
First published:	2016
Editors:	Donald E. Mager • Holly H C Kimko
Dimensions:	235 x 155 x 27mm (L x W x T)
Format:	Paperback
Pages:	511
Edition:	Softcover reprint of the original 1st ed. 2016
ISBN-13:	978-3-319-83074-2
Categories:	Books > Science & Mathematics > Mathematics > Applied mathematics > Mathematics for scientists & engineers Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	3-319-83074-0
Barcode:	9783319830742

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