The Cancer Degradome - Proteases and Cancer Biology (Hardcover, 2009 ed.)

Proteolysis is essential for life. From the breakdown of proteins in food for biosynthesis, through to antigen processing in the immune system, the blood cl- ting cascade, and the hormone-regulated remodelling of female reproductive tissues in adult mammals - proteolysis governs functionality, homeostasis, and fate at the levels of the cell and the entire organism. For the cancer cell, intracellular prote- ysis carried out by caspases and the proteasome must be enlisted and controlled to allow it to escape apoptosis. Functioning on the cancer cell surface or in the extracellular milieu, secreted proteases (primarily metalloproteinases, serine p- teases, and cathepsins) determine the interactions of cells with their environments. Once considered simply as promoting tumour cell invasion through tissue barriers, proteolysis is now known to be integral to many aspects of cancer biology, including angiogenesis, regulation of the bioavailability of growth factors, cellular adhesion, cytokine/chemokine signalling, in?ammatory cell recruitment, and the mobilization of normal cells from their tissue compartments to act as accomplices in metastasis. The last decade has witnessed a revolution in our thinking concerning the role of extracellular proteolysis in cancer biology: this is the primary focus of this book.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	September 2008
First published:	2008
Editors:	Dylan Edwards • Gunilla Hoyer-Hansen • Francesco Blasi • B.F. Sloane
Dimensions:	235 x 155 x 50mm (L x W x T)
Format:	Hardcover
Pages:	926
Edition:	2009 ed.
ISBN-13:	978-0-387-69056-8
Categories:	Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	0-387-69056-5
Barcode:	9780387690568

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