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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Implications of the Blood-Brain Barrier and Its Manipulation - Volume 2 Clinical Aspects (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R3,030
Discovery Miles 30 300
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Implications of the Blood-Brain Barrier and Its Manipulation - Volume 2 Clinical Aspects (Paperback, Softcover reprint of the original 1st ed. 1989)
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As a neurologist and student of the microvasculature, I find great
pleasure in introducing this treatise. Presented here is a view of
brain pathophysiology and therapy from the perspective of the
blood-brain barrier (BBB). Virtually every disease process that
affects the brain-traumatic, neoplastic, infectious, inflammatory,
toxic, metabolic, degenera tive, vascular, and epileptic-affects
the BBB. Damage to this homeostatic system often leads to
disruption of the composition and volume of brain fluid
compartments, thereby contributing to neurologic symptoms and
pathology. Furthermore, in disorders in which the integrity of the
barrier is not breached, its normal restrictive nature may limit
therapeu tic approaches. For example, the barrier appears to
function normally in Parkinson dis ease, but its ability to
compensate for striatal dopamine depletion is in part determined by
the activity of transporters and enzymes operative in the brain
microvasculature. of antibiotics, anticonvulsants, antineoplastic
agents, and neurolep Similarly, the choice tics requires attention
to these drugs' interaction with the BBB. Thus, the barrier inter
faces with virtually all nervous system diseases and therapies.
Future brain treatments with regulatory peptides, immune mediators,
and gene components will require selective methods to deliver these
agents to specific brain regions. The second volume of this text
successfully provides a thorough review of BBB function and failure
in a variety of clinical situations.
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