A new perspective on the design of molecular therapeutics is
emerging. This new strategy emphasizes the rational complementation
of functionality along extended patches of a protein surface with
the aim of inhibiting protein/protein interactions. The successful
development of compounds able to inhibit these interactions offers
a unique chance to selectively intervene in a large number of key
cellular processes related to human disease.
"Protein Surface Recognition" presents a detailed treatment of
this strategy, with topics including: an extended survey of
protein-protein interactions that are key players in human disease
and biology and the potential for therapeutics derived from this
new perspectivethe fundamental physical issues that surround
protein-protein interactions that must be considered when designing
ligands for protein surfacesexamples of protein surface-small
molecule interactions, including treatments of protein-natural
product interactions, protein-interface peptides, and rational
approaches to protein surface recognition from model to biological
systemsa survey of techniques that will be integral to the
discovery of new small molecule protein surface binders, from high
throughput synthesis and screening techniques to "in silico" and
"in vitro" methods for the discovery of novel protein ligands.
"Protein Surface Recognition" provides an intellectual
"tool-kit" for investigators in medicinal and bioorganic chemistry
looking to exploit this emerging paradigm in drug discovery.
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