Methods in Membrane Biology - Volume 10 (Paperback, Softcover reprint of the original 1st ed. 1979)

Three articles make up Volume 10 of Methods in Membrane Biology. In the first of these, Papahadjopoulos, Poste, and Vail extensively review much of the available data on the fusion of natural membranes, model membranes (liposomes), and natural membranes with liposomes. The authors are led by their review of the experimental methods and their interpretations of the results obtained to a general theory of membrane fusion which they believe is applicable to all systems that have been studied. Arguing that although protein and carbohydrate may serve, in some cases, to bring membranes into sufficiently close proximity for fusion to occur and, in other cases, to remove peripheral and integral proteins from the regions that are to undergo fusion, the authors conclude that membrane fusion per se is solely a property of the lipid bilayer. In their view, all the experimental observations to date can be subsumed under a unifying hypothesis in which membrane fusion is the result of a phase separation in one-half of the membrane bilayer brought about by the interaction - of calcium ions with acidic phospholipids, mostly phosphatidylserine. Where half-membranes already contain sufficient acidic phospholipids, a local increase in calcium ion concentration may suffice to induce fusion (examples might include exocytosis and fusion of intracellular membrane systems). In other cases, natural or experimentally induced events preceding fusion might be necessary to increase the local concentration of the acidic phospholipids in the half-membrane (virus-or fusogenic agent-induced cell-to-cell fusion, or endocytosis, for example).

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	August 2014
First published:	1979
Authors:	Edward D. Korn
Dimensions:	229 x 152 x 13mm (L x W x T)
Format:	Paperback
Pages:	227
Edition:	Softcover reprint of the original 1st ed. 1979
ISBN-13:	978-1-4684-0987-1
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Promotions
LSN:	1-4684-0987-5
Barcode:	9781468409871

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