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Books > Medicine > Clinical & internal medicine > Haematology
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Myelodysplastic Syndrome - From Diagnosis to Treatment (Hardcover)
Loot Price: R4,651
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Myelodysplastic Syndrome - From Diagnosis to Treatment (Hardcover)
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In this compilation, the authors review the biological aspects of
myelodysplastic syndrome disease, diagnosis, and treatment, as well
as innovations involving genetics and new treatment perspectives.
Myelodysplastic syndromes are a heterogeneous group of clonal
haematopoietic stem cells disorders characterized by dysplasia, as
well as peripheral blood cytopenias with a hypercellular marrow and
ineffective hematopoiesis. Myelodysplastic syndromes are frequently
associated with acute and chronic inflammation, and autoimmune
disorders such as: rheumatoid arthritis, bowel disease, diverse
types of vasculitis, autoimmune anemias, several rheumatic and skin
disorders, and certain thyroid disorders. Spliceosome mutations are
the most frequent mutations found in blood and bone marrow cells of
myelodysplastic syndromes patients. As such, the authors explore
the four predominant splicing factor genes: SF3B1, SFRS2, U2AF1,
ZRSR2. Subsequently, this collection discusses the CSNK1A1 gene in
the context of myelodysplastic syndromes. It is located at 5q32
within the deleted region, which encodes for casein kinase 1I+/-
(CK1I+/-). CK1I+/- is a component of a multiprotein I(2)-catenin
destruction complex that regulates Wnt/I(2)-catenin and p53
pathways. The concluding study focuses on the mutations in
epigenetic modifiers occur which myelodysplastic syndromes and
drive this disease, such as: DNA methylation, histone acetylation,
and RNA interference that alters gene expression.
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