The series of volumes entitled Biological Responses in Cancer
provides information on approaches through which the interaction
between neoplas tic and normal cells may be modified. Topics
discussed in various volumes include immunological and host defense
systems, control mechanisms of cell and population growth, cell
differentiation, and cell transformation. This volume is
specifically concerned with various aspects of cell interactions
and regulation within heterogeneous tumor cell populations, and
their role in tumor progression and metastasis. Knowledge in this
area is likely to provide new leads toward the exploitation of
novel cellular sites and mech anisms in the development of new
types of therapies of cancer. Several topics are discussed within
these general areas of consideration. The possibly unique
characteristics and mechanisms of tumor vascularization and the
potential sites of interference with angiogenesis that might have
therapeutic impli cations are critically evaluated. Tumor
cell-normal tissue interactions in volved in different phases of
the growth and metastatic processes are dis cussed in two chapters
dealing with mechanisms of tumor invasion and with the role of
collagen in mammary tumor growth; here again potential leads are
identified that may be exploited toward the development of new
thera peutic approaches. The evolution of phenotypic diversity as a
phenomenon complicating the biology of tumor metastasis and
consequently affecting the opportunities offered by chemotherapy is
also critically considered."
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