The discovery that nitrogen monoxide or nitric oxide (NO)is a
biologically produced free radical has revolutionized our thinking
about physiological and pathological processes. This discovery has
ignited enormous interest in the scientific community. When
generated at low levels, NO is a signaling molecule, but at high
concentration, NO is a cytotoxic molecule. The physiological and
pathological processes of NO production and metabolism and its
targets, currently areas of intensive research, have important
pharmacologic implications for health and disease.
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