A panel of leading investigators summarizes and synthesizes the new
discoveries in the rapidly evolving field of histone acetylation as
a key regulatory mechanism for gene expression. The authors
describe what has been learned about these proteins, including the
identification of the enzymes, the elucidation of the enzymatic
mechanisms of action, and the identification of their substrates
and their partners. They also review the structures that have been
solved for a number of enzymes-both alone and in complex with small
molecule inhibitors-and the biological roles of the several histone
deacetylases (HDAC) genes that have been knocked out in mice.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
Cancer Drug Discovery and Development |
| Release date: |
November 2010 |
| First published: |
2006 |
| Editors: |
Eric Verdin
|
| Dimensions: |
229 x 152 x 18mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
352 |
| Edition: |
Softcover reprint of hardcover 1st ed. 2006 |
| ISBN-13: |
978-1-61737-602-3 |
| Categories: |
Books >
Medicine >
Clinical & internal medicine >
Diseases & disorders >
Oncology >
General
|
| LSN: |
1-61737-602-7 |
| Barcode: |
9781617376023 |
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