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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Skin Carcinogenesis in Man and in Experimental Models (Paperback, Softcover reprint of the original 1st ed. 1993)
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Skin Carcinogenesis in Man and in Experimental Models (Paperback, Softcover reprint of the original 1st ed. 1993)
Series: Recent Results in Cancer Research, 128
Expected to ship within 10 - 15 working days
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The detection of cancer risk factors and their possible avoid ance
would most effectively contribute to the fight against cancer.
Research in these areas depends to a substantial degree on in vivo
experimental animal models and on epide miologic studies, including
data from cancer registries. When the Deutsches
Krebsforschungszentrum was founded in 1964, its division
"Mechanisms of Tumorigenesis" and a number of other divisions
became engaged in research on chemical carcinogenesis of the skin,
mainly using the mouse skin as an experimental model. Their
interest orig inated in part from investigations of the new and at
that time controversial pathogenic principle of conditional car
cinogens as represented by certain tumor promoters which are per se
noncarcinogenic. During the past 25 years, conditional carcinogens
in terms of tumor promoters were established as anew, nonclassical
category of cancer risk factors besides the classical solitary
carcinogens. In the course of this exciting period, scientists of
our center started cooperative programs with clinical dermato
logists of the University of Heidelberg at the Clinics of
Dermatology in Heidelberg and Mannheim, to extend the scope of
their investigations into clinical oncology and to contribute by
experimental approaches to solving problems in clinical oncology.
This led to a gradual shift from mere animal studies to the more
direct analyses of human tumors and opened up for us a new phase of
research.
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