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Incorporation of Heterocycles into Combinatorial Chemistry (Paperback, 1st ed. 2017)
Loot Price: R1,875
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Incorporation of Heterocycles into Combinatorial Chemistry (Paperback, 1st ed. 2017)
Series: SpringerBriefs in Molecular Science
Expected to ship within 10 - 15 working days
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The author has summarized a decade of teaching combinatorial
chemistry into this timely brief. The solid phase synthesis of
unnatural heterocyclic alpha-amino acids is illustrated by
practical examples starting from the ABCs of peptide synthesis
explored in chapter one. Chapter two is concerned with the solid
phase synthesis which is shown on various techniques - BillBoard,
tea-bag, and Lantern devices, and demonstrated on heterocyclic
examples and protocols. In the third chapter the tools for
accelerating chemical synthesis - solid phase and liquid phase -
are reviewed. Here the techniques of parallel refluxing (including
microwave and flow technique) and parallel separation (filtration,
centrifugation, evaporation, and chromatography) are described. In
the chapters 4 and 5 the author goes on to describe how the liquid
phase synthesis of heterocycles (reductive amination and Ugi
reaction of heterocycles) is illustrated with the use of
semi-automated protocols. Finally, the design of combinatorial
libraries of heterocycles is reviewed including the original
author's findings.
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