This monograph by Professor Alexandridis continues the proud
tradition of German ophthalmology in its discussion of the pupil
and its importance in the diagnosis of ocular, neurologic, and
systemic diseases. The first encyclopedic work on the pupil was
written by Wilbrand and Saenger at the end of the 19th century.
This redoubtable pair of physicians collected, analyzed, and clas
sified all the material available at that time, bringing order into
the previous chaos. The second major work was the book by C. v.
Behr shortly after World War 1. At that time, syphilis had been
accurately diagnosed with the aid of serologic tests, and
pharmacologic effects on the pupil had become well known. The third
significant development was initiated before World War II by the
neurologist Otto Lowenstein, whose work was later brilliantly
continued by his pupil and niece Irene Lowenfeld. The introduction
of their clinically useful pupillograph made quantitative analysis
possible. There followed a number of important contributions to the
knowledge of pupillary physiology and pathology, espe cially by
Harms in Tiibingen and Thompson in Iowa City. But the next decisive
contribution is this monograph by Alexandridis."
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