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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Vasodilators in Chronic Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1983)
Loot Price: R2,872
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Vasodilators in Chronic Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1983)
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The therapeutic principle of pharmacological vasodilation in
congestive heart failure is based upon established physiological
and pathophysiological mechanisms and has been proved to be
effective and useful. In acute heart failure this method of
treatment has assumed importance as the first measure to be taken.
In chronic heart failure a sizeable increase in cardiac output can
be achieved with a number of vasodilating drugs. This effect can be
maintained over several weeks or months. The adjustments of the
heart and the circulation to the arteriolar and/or venous unloading
effect of vasodilatation in the situation of acute and chronic
heart failure are well understood. However, long-term adaptations
of the organism to the vasodilat- ing intervention have not yet
fully been described. In many instances of chronic ad- ministration
of vasodilators, attenuation of the response has been observed. The
mech- anisms responsible have not been fully elucidated, nor has
there been a satisfactory demonstration of improved exercise
performance or of life expectancy under this mode of treatment in
the patient with chronic heart failure. In an attempt better to
understand the pathophysiological mechanisms of chronic congestive
heart failure as they apply to long-term treatment with
vasodilators, the working group on vasodilator therapy of the
Deutsche Gesellschaft fUr Herz- und Kreis- laufforschung has
assembled a group of physiologists, pharmacologists, and
clinicians. The Proceedings of their Symposium held in Hinterzarten
in June 1981 are presented here.
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