Preeclampsia is a hypertensive disorder of pregnancy. It affects
the health of both mother and fetus, and increases a woman's later
cardiovascular risk.Normally during pregnancy, the immune system
changes and women become more susceptible to infectious agents. Two
infectious agents in particular, C. pneumonia and CMV, are thought
to trigger early onset preeclampsia and have been linked to the
development of cardiovascular disease later in life. However, it is
still unclear what role they play in the onset and development of
preeclampsia.Dr. Xie is investigating the mechanisms between
infection, innate immune response and the development of
preeclampsia. In the present work, she studied how pregnant women
are affected by these two infectious agents and how immune system
responds to the infection, including examination of TLR signaling
and immune genetic variations that may increase disease
susceptibility. Results from her work will assist to identify novel
therapeutic targets for unfavorable pregnancy outcome management
and later cardiovascular disease prevention, leading to improved
health care for both mother and fetus.
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