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Computational Reconstruction of Missing Data in Biological Research (Paperback, 1st ed. 2021)
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Computational Reconstruction of Missing Data in Biological Research (Paperback, 1st ed. 2021)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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The emerging biotechnologies have significantly advanced the study
of biological mechanisms. However, biological data usually contain
a great amount of missing information, e.g. missing features,
missing labels or missing samples, which greatly limits the
extensive usage of the data. In this book, we introduce different
types of biological data missing scenarios and propose machine
learning models to improve the data analysis, including deep
recurrent neural network recovery for feature missings, robust
information theoretic learning for label missings and
structure-aware rebalancing for minor sample missings. Models in
the book cover the fields of imbalance learning, deep learning,
recurrent neural network and statistical inference, providing a
wide range of references of the integration between artificial
intelligence and biology. With simulated and biological datasets,
we apply approaches to a variety of biological tasks, including
single-cell characterization, genome-wide association studies,
medical image segmentations, and quantify the performances in a
number of successful metrics.The outline of this book is as
follows. In Chapter 2, we introduce the statistical recovery of
missing data features; in Chapter 3, we introduce the statistical
recovery of missing labels; in Chapter 4, we introduce the
statistical recovery of missing data sample information; finally,
in Chapter 5, we summarize the full text and outlook future
directions. This book can be used as references for researchers in
computational biology, bioinformatics and biostatistics. Readers
are expected to have basic knowledge of statistics and machine
learning.
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