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Phenotypes and Genotypes - The Search for Influential Genes (Hardcover, 1st ed. 2016)
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Phenotypes and Genotypes - The Search for Influential Genes (Hardcover, 1st ed. 2016)
Series: Computational Biology, 18
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This timely text presents a comprehensive guide to genetic
association, a new and rapidly expanding field that aims to
elucidate how our genetic code (genotypes) influences the traits we
possess (phenotypes). The book provides a detailed review of
methods of gene mapping used in association with experimental
crosses, as well as genome-wide association studies. Emphasis is
placed on model selection procedures for analyzing data from
large-scale genome scans based on specifically designed
modifications of the Bayesian information criterion. Features:
presents a thorough introduction to the theoretical background to
studies of genetic association (both genetic and statistical);
reviews the latest advances in the field; illustrates the
properties of methods for mapping quantitative trait loci using
computer simulations and the analysis of real data; discusses open
challenges; includes an extensive statistical appendix as a
reference for those who are not totally familiar with the
fundamentals of statistics.
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