Whereas genetic studies have traditionally focused on explaining
heritance of single traits and their phenotypes, recent
technological advances have made it possible to comprehensively
dissect the genetic architecture of complex traits and quantify how
genes interact to shape phenotypes. This exciting new area has been
termed systems genetics and is born out of a synthesis of multiple
fields, integrating a range of approaches and exploiting our
increased ability to obtain quantitative and detailed measurements
on a broad spectrum of phenotypes. Gathering the contributions of
leading scientists, both computational and experimental, this book
shows how experimental perturbations can help us to understand the
link between genotype and phenotype. A snapshot of current research
activity and state-of-the-art approaches to systems genetics are
provided, including work from model organisms such as Saccharomyces
cerevisiae and Drosophila melanogaster, as well as from human
studies.
General
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