Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Brain Tumors (Hardcover, 2005 ed.)
Loot Price: R5,735
Discovery Miles 57 350
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Brain Tumors (Hardcover, 2005 ed.)
Series: Contemporary Cancer Research
Expected to ship within 10 - 15 working days
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Exciting new developments and discoveries of the last two decades
are beginning to shed light on the complex biology of brain tumors
and are advancing our understa- ing of the cellular and molecular
processes involved in their initiation, progression, and clinical
and biological behavior. The disease process in brain tumors is
quite complex and the resulting tumors are characterized by a high
degree of biological and clinical diversity. Thus, despite the
advances of the last two decades, prognosis for patients with
malignant brain tumors remains abysmal. Significant progress in the
diagnosis, treatment and, ultimately, prevention of these tumors
will require both the timely h- nessing of the advances in basic
and clinical brain tumor research, and a continuing concerted
effort at increasing our understanding of brain tumor biology, in
particular, the molecular genetic changes and perturbations of
cellular pathways involved in brain oncogenesis and which drive the
biological and clinical behavior of the tumors. Brain tumor
diagnosis and prognosis, which is still largely based on
histopathology and other clinical criteria, will, in the future,
acquire a significant molecular component, with the incorporation
of knowledge of genes that are mutated, over-expressed, deleted,
silenced, or functionally altered in the tumors. Treatment
strategies for brain tumors, rather than being empirical, will be
rationally developed based on an understanding of the cellular and
molecular mechanisms and targets that have been activated,
suppressed, or otherwise altered.
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