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Advances in Plasma Physics Research - Volume 6 (Hardcover, New)
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Advances in Plasma Physics Research - Volume 6 (Hardcover, New)
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Alzheimer's disease (AD), the most common form of neurodegenerative
disorder in the elderly, is characterised pathologically by
extracellular amyloid plaques and intracellular neurofibrillary
tangles, pathophysiologically by synaptic dysfunction, and
clinically by a progressive decline in cognition. Currently, AD has
no cure and its prevalence is predicted to triple by 2050 with the
rapid increase in the ageing population, unless more effective
treatments are developed. Since the publication of the second book
volume, the rapid progress in the research fields of AD and
dementia continues through the intensive efforts of research
scientists worldwide.This third book volume contains 15 chapters,
bringing together a presentation of research frontiers in current
AD/dementia research. The topics include molecular genetics of AD,
gene expression abnormalities in AD progression, presenilins,
taupathy in AD, single - induced(neuron gene expression
abnormalities in AD, intracellular A neurodegeneration, roles of
lipoprotein receptors in AD onset and progression, cholesterol and
tau hyperphosphorylati-on, AD diagnostics and therapeutic
strategies, in vivo visualisation of amyloid-like structures,
cathepsin B, antiamyloidogenesis and neuroprotection, environmental
enrichment, Fragile X mental retardation gene and dementia,
category learning in Parkinson's disease, cerebrovascular disease
and dementia, and dementia and hypertension.These chapters cover
current advances in our understanding of the pathogenic mechanisms
underlying AD and dementia, in the diagnosis of early AD and
dementia, and in the development of therapeutic agents that target
memory-relevant AD pathogenesis. The book will be highly valuable
to students and scientists worldwide who are interested in the
scientific research progress in AD and dementia.
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