Oxidative stress is the result of an imbalance in
pro-oxidant/antioxidant homeostasis that leads to the generation of
toxic reactive oxygen species. Brain cells are continuously exposed
to reactive oxygen species generated by oxidative metabolism, and
in certain pathological conditions defense mechanisms against
oxygen radicals may be weakened and/or overwhelmed. DNA is a
potential target for oxidative damage, and genomic damage can
contribute to neuropathogenesis. It is important therefore to
identify tools for the quantitative analysis of DNA damage in
models on neurological disorders. This book presents detailed
information on various neurodegenerative disorders and their
connection with oxidative stress. This information will provide
clinicians with directions to treat these disorders with
appropriate therapy and is also of vital importance for the drug
industries for the design of new drugs for treatment of
degenerative disorders.
* Contains the latest information on the subject of
neurodegenerative disorders
* Reflects on various factors involved in degeneration and gives
suggestions for how to tackle these problems
General
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