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Epileptogenic & Excitotoxic Mechnaisms (Paperback)
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Epileptogenic & Excitotoxic Mechnaisms (Paperback)
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This volume is based on an advanced course on epileptogenic and
excitotoxic mechanisms with emphasis on development. Information on
partial and generalised epileptogenesis, derived from different
experimental models, is comprehensively reviewed. Special sections
are devoted to anatomical, biochemical and functional aspects of
the maturing brain and to their interaction with epileptogenic
agents. Several seizure-related factors, for example an
intracellular rise of calcium, can lead to excitotoxic cellular
damage. Despite some protective mechanisms, this risk is
particularly worrying in the immature brain due to the
over-expression and facilitation of NMDA receptors, the
depolarising effect of GAGA and the immaturity of ionic
homoeostasis. Seizures in early developmental stages can thus
result in permanent defects and epileptic sequelae. Our present
understanding of basic mechanisms of the epilepsies allows
pharmacologists to design new drugs with specific pharmacological
action targeted on crucial epileptogenic factors. These results,
together with those of developmental studies of excitotoxicity,
provide a basis for new therapeutic strategies aimed at preventing
the development of severe infantile epileptic encephalopathies and
at alleviating their dramatic consequences. The authors have
combined their personal experience with a comprehensive review of
the literature, providing the reader, either scientist or
clinician, with an updated and exhaustive account of every topic.
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