The most feared attribute of the human pathogen "Vibrio
cholerae" is its ability to cause outbreaks that spread like
wildfire, completely overwhelming public health systems and causing
widespread suffering and death. This volume starts with a
description of the contrasting patterns of outbreaks caused by the
classical and El Tor biotypes of "V. cholerae." Subsequent chapters
examine cholera outbreaks in detail, including possible sources of
infection and molecular epidemiology on three different continents,
the emergence of new clones through the bactericidal selection
process of lytic cholera phages, the circulation and transmission
of clones of the pathogen during outbreaks and novel approaches to
modeling cholera outbreaks. A further contribution deals with the
application of the genomic sciences to trace the spread of cholera
epidemics and how this information can be used to control cholera
outbreaks. The book closes with an analysis of the potential use of
killed oral cholera vaccines to stop the spread of cholera
outbreaks.
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