The application of systems biology methods to Traditional Chinese
Medicine
Emphasizing the harmony of the human body with the environment,
Traditional Chinese Medicine (TCM) has evolved over thousands of
years. It is a systemic theory derived from clinical experience,
the philosophy of holism and systematology, and the belief that man
is an integral part of nature.
"Systems Biology for Traditional Chinese Medicine" describes how
the latest methods in systems biology can be applied to TCM,
providing a comprehensive resource for the modernization and
advancement of TCM as well as general drug discovery efforts. It is
the first comprehensive work to propose a system-to-system research
methodology to study the interaction between TCM and the human body
and its applications in drug research and development.
Using three popular traditional Chinese
medicines--Shuanglongfang, Qingkailing, and Liushenwan--as
examples, the authors set forth case examples demonstrating how to
find material groups, perform efficacy screenings, and conduct
safety evaluations of TCM. The book also: Describes the mechanisms
of TCM at the molecular and systems levels using chemomics,
genomics, proteomics, metabolomics, and bioinformaticsPlaces modern
scientific technologies within the context of TCM, helping drug
researchers improve experimental designs and strategiesIllustrates
how a systems biology approach is compatible with TCM's
traditional, holistic therapeutic strategies and treatment
modalitiesPresents topics of current interest, such as integrated
global systems biology and the application of chemometrics research
to herbal medicines
This book not only opens a new pathway for the continued
development of TCM, but also for systems biology. In addition, it
fosters collaboration and discussion among Eastern and Western
scientists by applying systems biology to TCM.
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