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Atherosclerosis - is it reversible? (Paperback)
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Atherosclerosis - is it reversible? (Paperback)
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Even though numerous questions with regard to the pathogenesis of
athero sclerosis have not yet been answered, the accumulated
evidence indicates significant regression of lesions in
experimental animals. This is discussed extensively in this
monograph, as are the mechanisms involved in regression of lesions.
Whether human atherosclerosis has the potential for regression
appears to be the most important, but at the same time the most
difficult question to answer. Contrary to experimental
atherosclerosis in animals, which can be produced and which can
regress within a few months, human lesions in general develop
slowly over many years. Therefore, measures aimed at modifying this
process may also require many years to be successful. In addition,
repeated direct examination of lesions in the human is usually not
possible. Nevertheless, recent reports in patients with
hyperlipoproteinemias indicate that pronounced and maintained
control of hyperlipidemias may lead, even within months, to
regression as evidenced by angiography or sophisticated
measurements of peripheral circulation. The monograph is divided
into two sections. The first will deal with of lipid deposition in
the arterial wall, whether "atherogenesis" mechanisms or not there
is evidence of monoclonal origin of human atherosclerosis plaques,
cell culture and factors that stimulate smooth muscle
proliferation, and animal models of atherogenesis. This section is
concluded with a discussion of dietary factors other than lipids in
atherogenesis."
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