The human immunodeficiency viruses (HIVs), in particular HIV-1, are
the causative agent responsible for the current worldwide epidemic
of acquired immunodeficiency syndrome (AIDS). A major effort has
thus been underway over the past two decades to understand and
control this pathogen. During this time, an enormous knowledge base
has accumulated regarding the role of viral factors in the HIV-1
life cycle, and the interaction of HIV-1 with the host cell is
becoming increasingly understood. Certain features of HIV, for
example its ability to infect non-dividing cells, are being
exploited in the development of novel gene therapy vehicles. This
volume provides an overview of the current information regarding
the HIV replication cycle and will serve as an introduction to
subsequent chapters that address specific aspects of
lentiviral-based gene therapy.
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