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Diversity, Versatility & Leukaemia (Hardcover)
Loot Price: R3,422
Discovery Miles 34 220
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Diversity, Versatility & Leukaemia (Hardcover)
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The blood cell system has provided a model system that has been
used by many researchers to investigate how a stem cell can give
rise to a wide variety of mature cell types. The principles that
emerged in developmental biology have been applied to the structure
of tissues throughout the body. However, many of the principles
have been challenged by recent findings, changing the way we view
blood cell development. In turn, this has impacted our
understanding of the origin and nature of leukaemia, as well as
cancer in general. Like the development of any body tissue, cancer
is an organised and hierarchical tissue with its own identity. A
new viewpoint is that the mutations that give rise to cancer
re-programme cancer cells to their own abnormal pattern of tissue
development. Understanding how the hierarchy of tumour identity
differs from that of normal tissue provides important new avenues
to the development of new treatments for cancer. No doubt further
refinement to our understanding of normal and cancer cells will
continue for many years to come. Even so, we appear to be moving
towards an exciting prospect of providing the key to unlocking the
long standing mystery of primary cellular events that undermine and
distort our normal cells and give rise to the disease of cancer.
The importance of this is the prospect of developing new treatments
for cancer. In particular, the distorted behaviour of cancer cells
might be reversible so that they can be restored to their normal
state. Diversity, Versatility and Leukaemia examines how normal and
cancer cells are inextricably linked, and focuses on the changes to
how we view the development of normal cells and the subversion of
this process in cancer.
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