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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Glycobiology Research Trends (Hardcover)
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Glycobiology Research Trends (Hardcover)
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Glycobiology is the study of the structure, biosynthesis and
biology of saccharides that are widely distributed in nature and
are essential components of all living things. This field combines
expertise in both carbohydrate biochemistry and molecular biology.
The ABC drug transporter, P glycoprotein or MDR1 is one such
example discussed in this book. The relationship of
glycosphingolipid (GSL) biosynthesis to the Pgp-mediated multiple
drug resistance phenotype, and the role of MDR1 in lipid
biosynthesis in particular is evaluated. The structure and
activities of natural complex polysaccharides are also analysed.
Specifically, heparin (Hep) as an anticoagulant and antithrombotic
(macro)molecule and CS in the treatment of osteoarthritis is
reviewed, and the GAG structure-function relationship, which has
led to the discovery of novel drugs for the possible treatment of
some serious diseases. The gene targeting analyses of certain
enzymes, which revealed that the HNK-1 carbohydrate plays important
roles in synaptic plasticity and memory function, is described as
well. Recent work on the topic "protein-specific glycosylation" is
highlighted also, focusing on the primary structure of a protein
which directly exerts a cis-control of the glycosylation event.
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