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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Processing of VEGF-C and -D by the Proprotein Convertases - Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis (Paperback)
Loot Price: R1,464
Discovery Miles 14 640
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Processing of VEGF-C and -D by the Proprotein Convertases - Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis (Paperback)
Series: Colloquium Series on Protein Activation and Cancer
Expected to ship within 18 - 22 working days
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The vascular endothelial growth factor (VEGF) family members that
include VEGF-A, -B, -C, -D, and placental growth factor (PlGF),
display distinct binding affinities for their receptors VEGFR-1,
-2, and/or -3. In addition to their requirements in the initiation,
development, and maintenance of blood and lymphatic vasculature,
VEGFs and VEGFRs are upregulated during neoplasia and are involved
in the remodeling of tumoral blood and lymphatic vasculature. By
activating VEGFR-1 and VEGFR-2, both expressed on blood endothelial
cells, VEGF-A promotes the formation of new tumoral blood vessels
and thereby accelerates tumor growth. In contrast, upregulation of
VEGF-C, a ligand for lymphatic endothelial VEGFR-3 as well as for
VEGFR-2, induces the formation of tumor-associated lymphatic
vessels and thus promotes the passive metastatic dissemination of
tumor cells to regional lymph nodes. Of the VEGF family members,
only VEGF-C and -D were found to be proteolytically processed by
Furin-like enzymes. This processing controls the selective
activation of VEGFR-2 and -3 signaling during tumor angiogenesis
and lymphangiogenesis. Here, we provide an overview of angiogenesis
processes and discuss the importance of VEGF-C and VEGF-D
precursors processing by the proprotein convertases during the
activation of VEGFR-2 and VEGFR-3 receptors and the mediation of
their functions during angiogenesis, lymphangiogenesis, and
tumorigenesis.
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