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DNA Tumor Viruses - Oncogenic Mechanisms (Hardcover, 1995 ed.)
Loot Price: R5,704
Discovery Miles 57 040
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DNA Tumor Viruses - Oncogenic Mechanisms (Hardcover, 1995 ed.)
Series: Infectious Agents and Pathogenesis
Expected to ship within 10 - 15 working days
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DNA tumor viruses have long been useful experimental models of
carcinogenesis and have elucidated several important mechanisms of
cell transformation. Re search in recent years has shown that human
tumors have a multifactorial nature and that some DNA tumor viruses
may playa key role in their etiology. The aim of this book is to
assess our knowledge of DNA tumor viruses by reviewing animal
models, mechanisms of transformation, association with human
tumors, and possi bilities of prevention and control by
vaccination. Animal models of tumor virology have contributed
significantly to our under standing of the epidemiology and
pathogenesis of virus-induced tumors. Bovine papillomaviruses
induce papillomas in the intestine of cattle. The papillomas
undergo a transition to carcinomas in cows feeding on bracken fern,
which pro duces a toxin with radiomimetic and immunosuppressive
functions. This example of cooperation between a virus and chemical
carcinogens parallels the cooperative role of human
papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2)
with environmental carcinogens in the pathogenesis of cervical
cancer. Likewise, hepatocarcinomas appearing in woodchucks
chronically infected by woodchuck hepatitis virus (WIN) provide
strong support for the relationship between hepatitis B virus (HBV)
infection and human hepatocellular carcinoma. Also, the fact that
WIN DNA integrates closely to cellular oncogenes suggests a
possible molecular mechanism for the tumorigenesis induced by HBV."
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