Along with AIDS, antiphospholipid syndrome was the major medical
discovery of the late 20th century, so for many it is still deemed
a 'new' disease.
The discovery of 'sticky blood' (commonly known as
antiphospholipid syndrome or 'Hughes Syndrome') came out of years
of observation of patients who had developed lupus. Many
specialists in the 1970s were interested in the neurological
aspects of lupus, and Dr Hughes, among others, spent a number of
years studying the mechanisms of brain inflammation.
In the mid 1970s, Hughes observed a number of young women with a
form of viral paralysis, where interestingly many of them carried
an antibody in their blood actually directed against 'phospholipid'
- one of the components of brain and spinal cord. It quickly became
apparent that individuals who had "anti-phospholipid antibodies"
suffered from a tendency not only to develop brain and spinal cord
symptoms, but also a tendency to develop both vein and artery
thrombosis.
As investigation continued it became apparent that these
symptoms were not just confined to lupus patients, but occurred in
others too, specifically those with severe migraines, with repeated
strokes, with memory loss, and in women with recurrent
miscarriage.
General
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