Books > Medicine > Clinical & internal medicine > Otorhinolaryngology (ENT)
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Ototoxicity - Signs, Symptoms and Treatment (Paperback)
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Ototoxicity - Signs, Symptoms and Treatment (Paperback)
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Total price: R2,020
Discovery Miles: 20 200
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This compilation focuses on Ototoxicity, the adverse
pharmacological reaction affecting the inner ear or auditory nerve,
characterised by cochlear or vestibular dysfunction. Although
ototoxic medications play an essential role in modern medicine,
they can cause harm and lead to significant morbidity. The authors
discuss aminoglycoside antibiotics, loop diuretics, platinum-based
chemotherapeutic agents, macrolide antibiotics and antimalarial
medications which are among the 600 frequently used ototoxic drugs.
Next, an overview of cisplatin-associated ototoxicity, namely its
clinical features, incidence rates, molecular and cellular
mechanisms and risk factors is provided for health care
practitioners managing patients with cancer. Ototoxicity and
neurotoxicity are defined from the perspective of chemical agents,
nicotine and cotinine, that individuals experience through
cigarette smoking and environmental tobacco smoke exposure.
Mechanisms for toxicity are described by review of animal and human
studies revealing changes in peripheral and central auditory
structures after exposure to nicotine. The mechanisms of
ototoxicity induced by aminoglycoside are also discussed, as well
as the usage of these drugs for treatment of several disorders such
as Meniere disease, and possible protective agents. In closing, the
authors highlight the serious issue of aminoglycoside mediated
hearing loss in cystic fibrosis patients, and also discuss
alternative approaches for avoiding aminoglycoside-induced
cochleotoxicity.
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