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Psychopharmacoendocrinology and Depression Research (Paperback)
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Psychopharmacoendocrinology and Depression Research (Paperback)
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1.1 Outline of the Study In this study the influence of
psychotropic drugs on anterior pituitary hormone (APR) secretion
was investigated in healthy subjects and in depressed patients. The
basis for this study is formed by pharmacological investigations
which indicate that the therapeutic effect of psychotropic drugs
can be attributed to their functional influence on central nervous
aminergic impulse transmission (stimuli) as well as by
endocrinological investigations which show that central nervous
aminergic neurons influence APR secretion in man. The purpose was
to frod out if psychotropic drugs with differing pharmacological
actions also influence APR secretion differently, even though the
complex processes of central nervous stimuli transmission, the
effect of psychotropic drugs on these processes, as well as the
action of aminergic neuronal systems on APR secretion are not
completely understood. Furthermore, it was investigated if it is
possible to reach conclusions on the effects of drugs on central
nervous aminergic neurons based upon APR secretion data.
Specifically, the effects of various antidepressants, neuroleptics,
and benzodiazepine-type tranquilizers on the secretion of growth
hormone (GR), prolactin (PRL), adrenocorticotropic hormone (ACTR),
and cortisol were investigated in healthy male subjects. The first
part of this study presents in detail the results of these
experiments and also incorporates the results of other
investigators. It is endeavored to answer the question whether and
to what extent the different psychotropic drugs influence APR
secretion and whether the APR secretion profiles of the different
psychotropic drugs can serve as a possible pharmacoendocrinological
model in humans.
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