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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Cancer Virus Hunters - A History of Tumor Virology (Hardcover)
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Cancer Virus Hunters - A History of Tumor Virology (Hardcover)
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Traces the history of the study of tumor viruses and its role in
driving breakthroughs in cancer research. Worldwide, approximately
one-fifth of human cancers are caused by tumor viruses, with
hepatitis B virus and HPV being the leading culprits. While the
explosive growth in molecular biology in the late twentieth century
is well known, the role that the study of tumor viruses has played
in driving many of the greatest breakthroughs is not. Without the
insights gained by studying tumor viruses, many significant
theoretical advancements over the last four decades in cellular and
molecular biology would not have been made. More practically, the
study of tumor viruses has saved thousands, if not millions, of
lives. In Cancer Virus Hunters, Gregory J. Morgan traces the high
points in the development of tumor virology, from Peyton Rous's
pioneering work on chicken tumors in 1909 to the successful
development of an HPV vaccine for cervical cancer in 2006. Morgan
offers a novel approach to understanding the interconnectedness of
a long series of biomedical breakthroughs, including those that led
to seven Nobel prizes. Among other advances, Morgan describes and
contextualizes the science that prompted the discoveries of reverse
transcriptase, RNA splicing, the tumor suppressor p53, the vaccine
for hepatitis B, and the HIV test. He also explores how "cancer
virus hunters" have demonstrated the virtue of beginning with a
simple system, even when investigating a complex disease like
cancer. Based on extensive archival research and over fifty
interviews with experts, Cancer Virus Hunters is a tour de force
summarizing a century of research to show how discoveries made with
tumor viruses came to dominate the contemporary understanding of
cancer. By showcasing the scientists themselves, the book makes for
an unusually accessible journey through the history of science. It
will be of interest to biomedical professionals-especially in
oncology, hepatology, and infectious disease-in addition to
historians of science and anyone interested in cancer research.
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