A state-of-the-art review of the molecular underpinnings of
bone-seeking cancers, current treatment approaches for them, and
future therapeutic strategies. The authors illuminate the role of
various autocrine, paracrine, and immunological factors involved in
the progression and establishment of bone metastases, highlighting
the physiological processes that lead to bone degradation, pain,
angiogenesis, and dysregulation of bone turnover. They also discuss
the various strategies that appear to have promise and are
currently deployed in treatment or are at the experimental stage.
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